可以使用 __in ，示例如下：

 Comment.objects.filter(user_id__in=[1,2,3,4,5]).order_by['-create_time'][0]

官方文档在 这里 。

如果你的comment_id是自增长的话

 sql


 select * from comments where comment_id in (
    select max(comment_id) as comment_id from comments
    where user_id in (1, 2, 3, 4, 5)
    group by user_id
)

如果comment_id不是自增长，create_time也可以将就，同一用户应该不会出现create_time重复的情况

 sql


 select * from comments where create_time in (
    select max(create_time) as create_time from comments
    where user_id in (1, 2, 3, 4, 5)
    group by user_id
) and user_id in (1, 2, 3, 4, 5)